Ok, but bear in mind that getting good deliverability with any bulk mailer is an art from It requires a lot of work, skills and time.
There is a plugin for autoresponders, and you set up bounce processing yourself according to your desires (there is a chapter in the manual to help)
In self hosted you assure this yourself. You can throttle domains, but on a shared IP it’s affected by what other people are doing too (which is out of your control) and you will need to deal with any blocks or blacklisting yourself.
This is possible to set up, its in the config file. It’s a prettey slow speed though no?