Use different configs for different SMTP servers and lists?

eg. I have more lists of users from different countries and I need to use different domains for sending emails. How to, please? Can I use eg. 4 cron jobs to process the queue and different config.php renamed files? eg. config1.php, config2.php and so on…or ? Can you better explain how to manage more lists with different SMTP servers?

thanks, best regards