Configuration sender

Hello,
I have several mailing lists that correspond to several activities.
I now have one domain name per activity.
Is it possible to manage it with phplist.
ex: list1 with xxx.com with my mailing address infos@xxx.com list2, and xxxx.eu with infos@xxx.eu.
it’s important not to get blacklisted…
For the moment I change my configuration file every time and it works but it’s boring…
is there a simpler solution?
tk